Phenotypes Associated with This Genotype

Genotype
MGI:3510460

• Allelic Composition: Tg(AZIP/F)1Vsn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:50807 )

• transgenic mice are more sensitive to death after anesthesia than wild-type mice

premature death ( J:50807 )

• survival after weaning is reduced

postnatal lethality ( J:50807 )

• normal numbers of transgenic pups are born however by weaning the percentage of transgenic pups is decreased to 30% (from 50%)

• almost no pups from litters produced by hemizygous females survive until weaning

adipose tissue

decreased brown adipose tissue amount ( J:50807 )

• transgenic mice have decreased brown fat at birth which is primarily inactive and resembles white adipose tissue

decreased white adipose tissue amount ( J:50807 )

• transgenic mice have essentially no white fat as a result of a failure to generate white adipose tissue cells

behavior/neurological

polydipsia ( J:50807 )

• transgenic mice drink 4 times more than wild-type mice

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:50807 )

• the islet cells are hyperplastic and hypertrophic with a large increase in the number of beta cells

growth/size/body

weight loss ( J:50807 )

• when fasted adult transgenic mice lose weight faster than non-transgenic mice

increased body weight ( J:50807 )

• transgenic mice are heavier than wild-type mice at 8-11 weeks of age as a result of an increase in the weights of multiple organs including the liver, heart, kidneys, and spleen

• transgenic mice have increased abdominal girth compared to wild-type mice

postnatal growth retardation ( J:50807 )

• transgenic mice grow slower than wild-type mice before weaning, weighing 50% and 80% of wild-type weight at 1 and 3 weeks of age, respectively

increased liver weight ( J:50807 )

• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice

homeostasis/metabolism

decreased circulating leptin level ( J:50807 )

• free active leptin levels are about 5% of wild-type mice

abnormal glucose homeostasis ( J:50807 )

hyperglycemia ( J:50807 )

• serum glucose is increased about 3-fold compared to wild-type mice

• elevated serum glucose is first detected 3 weeks after birth and reaches diabetic levels by 4 weeks

• when fasted serum glucose levels drop to a much greater extent than in non-transgenic mice

increased circulating insulin level ( J:50807 )

• serum insulin levels are increased 58- and 442-fold in male and female transgenic mice

• insulin levels are already elevated 30-fold by 1 week after birth

• when fasted serum insulin levels drop to a much greater extent than in non-transgenic mice

abnormal lipid homeostasis ( J:50807 )

increased circulating free fatty acids level ( J:50807 )

• circulating free fatty acid are increased 1.5- to 2.5 fold compared to wild-type mice however no signs of ketosis are detected

• when fasted circulating free fatty acid levels drop rather than rise as in wild-type mice

increased circulating triglyceride level ( J:50807 )

• serum triglyceride levels are elevated 3- to 5-fold

increased liver triglyceride level ( J:50807 )

• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:50807 )

• transgenic mice are more sensitive to death after anesthesia than wild-type mice

liver/biliary system

increased liver weight ( J:50807 )

• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice

increased liver triglyceride level ( J:50807 )

• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice

hepatic steatosis ( J:50807 )

• the liver is pale with lipid accumulation in a zone 3/centrilobular pattern

renal/urinary system

polyuria ( J:50807 )

• transgenic mice have a significantly higher urine output than normal

reproductive system

reduced female fertility ( J:50807 )

♀ • females have reduced fertility and litter size with almost no pups surviving until weaning

reduced male fertility ( J:50807 )

♂ • male fertility is decreased but litters that are produced are of normal size

respiratory system

abnormal lung morphology ( J:50807 )

• lipid loaded phagocytic cells are seen in the lungs of some transgenic mice