Analysis Tools
mortality/aging
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• many homozygotes die shortly after birth
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• only 1 of 227 mice at 10-20 days of age was a homozygote
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cardiovascular system
hemorrhage
(
J:29796
)
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• at E16.5 extensive hemorrhaging is seen in all homozygotes but by E18.5 hemorrages are seen in only 45% of homozygotes
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immune system
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• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells
• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells
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• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type
• T cell numbers in the skin are reduced to about 60% of wild-type
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homeostasis/metabolism
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• chylous ascites are seen after pups begin feeding
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hematopoietic system
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• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells
• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells
|
|
• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type
• T cell numbers in the skin are reduced to about 60% of wild-type
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