Phenotypes for Meox2 Nodal MGI:3056368 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Nodal^tm1Rob/Nodal^tm5Rob
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (21 available)
Nodal^tm1Rob mutation (2 available); any Nodal mutation (41 available)
Nodal^tm5Rob mutation (0 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal developmental patterning ( J:93140 )

• development was variable

abnormal proximal-distal axis patterning ( J:93140 )

• fail to rotate their proximal distal axis

rostral body truncation ( J:93140 )

• variable amounts of anterior truncation at E6.5

• in severe cases an elongate morphology at E6.5

• profound anterior truncations by E8.5

abnormal visceral yolk sac morphology ( J:93140 )

• embryos occasionally protrude outside the yolk sac at E6.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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