Phenotypes Associated with This Genotype

Genotype
MGI:3056346

• Allelic Composition: Rad17^tm1Maas/Rad17^tm1Maas
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93156 )

• embryos begin to die after E8.5 with no viable embryos found after E11.5

cardiovascular system

abnormal heart morphology ( J:93156 )

• at E11.5 in most embryos heart abnormalities are seen

hemorrhage ( J:93156 )

• at E11.5 bleeding is seen in the rhombencephalon, mesencephalon, prosencephalon, heart, and liver

embryo

abnormal pharyngeal arch morphology ( J:93156 )

• delays and abnormalities in pharyngeal arch development are seen in most embryos at E11.5

abnormal neural tube morphology ( J:93156 )

• delays and abnormalities in neural tube development are seen including failure to close the head folds in most embryos at E11.5

incomplete somite formation ( J:93156 )

• at E11.5 embryos have fewer somites

liver/biliary system

abnormal liver morphology ( J:93156 )

• at E11.5 in most embryos liver abnormalities are seen

nervous system

abnormal neural tube morphology ( J:93156 )

• delays and abnormalities in neural tube development are seen including failure to close the head folds in most embryos at E11.5

craniofacial

abnormal pharyngeal arch morphology ( J:93156 )

• delays and abnormalities in pharyngeal arch development are seen in most embryos at E11.5