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Phenotypes Associated with This Genotype
Genotype
MGI:3056193
Allelic
Composition		 Hdac5tm1Eno/Hdac5tm1Eno
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:93021 )
• transgenic mice are highly susceptible to sudden death from heart failure with none surviving beyond 8 weeks of age

cardiovascular system
cardiac hypertrophy ( J:93021 )
• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy

growth/size/body
cardiac hypertrophy ( J:93021 )
• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory