Mouse Genome Informatics
ht
    Brca2tm1Mhun/Brca2+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• remain tumor free for over a year
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

cellular
• mammary tumor cell lines grew significantly faster after the third day in culture
• very sensitive to DMBA induced apoptosis

homeostasis/metabolism
• delayed tumor development in response to medroxyprogesterone acetate as compared to controls
• predominantly mammary tumors

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:89083