Phenotypes Associated with This Genotype

Genotype
MGI:3055514

• Allelic Composition: Kit^W-44J/Kit^W-44J
• Genetic Background: B6.C3-Kit^W-44J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovary morphology ( J:6571 )

♀ • pathological invagination of the germinal epithelium by 2 months of age

abnormal ovarian follicle number ( J:6571 )

♀ • ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

♀

reduced female fertility ( J:6571 )

♀ • 50% are fertile and these produce one or two small litters

decreased litter size ( J:6571 )

• some female mice produce small litters

male infertility ( J:6571 )

♂ • testes are less than a third normal size and devoid of spermatogenic activity

hematopoietic system

hematopoietic system phenotype ( J:6571 )

N • no hematopoietic system abnormalities detected

pigmentation

irregular coat pigmentation ( J:6571 )

• mice exhibit a black-flecked white coat in which the dorsal coat has concentrated areas of black about the head and hind quarters and the ventral coat is white with black hair along lateral borders

endocrine/exocrine glands

abnormal ovary morphology ( J:6571 )

♀ • pathological invagination of the germinal epithelium by 2 months of age

abnormal ovarian follicle number ( J:6571 )

♀ • ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

♀

integument

irregular coat pigmentation ( J:6571 )

• mice exhibit a black-flecked white coat in which the dorsal coat has concentrated areas of black about the head and hind quarters and the ventral coat is white with black hair along lateral borders