Phenotypes Associated with This Genotype

Genotype
MGI:3055363

• Allelic Composition: Stat5a^tm2Mam/Stat5a^tm2Mam; Stat5b^tm1Mam/Stat5b^tm1Mam; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal milk ejection ( J:92770 )

♀ • 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

♀ • the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

♀ • treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

integument

abnormal milk ejection ( J:92770 )

♀ • 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk

abnormal branching of the mammary ductal tree ( J:92770 )

♀ • the number of tertiary branches is severely decreased, the lobular units are absent, and at parturition the alveolar compartment is missing

♀ • treatment with estrogen and progesterone induces very little side branching in mammary epithelia unlike in wild-type females

behavior/neurological

abnormal milk ejection ( J:92770 )

♀ • 10 out of 12 dams were unable to secrete milk, while the remaining 2 could secrete only small amounts of milk