Phenotypes Associated with This Genotype

Genotype
MGI:3055137

• Allelic Composition: Cd22^tm3Tft/Cd22^tm3Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in vivo in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells is reduced when backcrossed to C57BL/6 for 6 generation but not in the early generations with a greater contribution of 129 derived genes

• the number of B cells in the blood and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in vivo in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells is reduced when backcrossed to C57BL/6 for 6 generation but not in the early generations with a greater contribution of 129 derived genes

• the number of B cells in the blood and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in vivo in all tissues