Phenotypes Associated with This Genotype

Genotype
MGI:3055136

• Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues