Phenotypes Associated with This Genotype

Genotype
MGI:3055026

• Allelic Composition: Dld^tm1Ptl/Dld^tm1Ptl
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:45074 )

• homozygous null embryos exhibit peri-gastrulation lethality and are resorbed by 9.5 dpc

embryo

embryonic growth arrest ( J:45074 )

• homozygous null embryos display a developmental cessation at the onset of gastrulation

• no mutant embryos develop normally to 8.5 dpc

embryonic growth retardation ( J:45074 )

• homozygous null embryos display a developmental delay at 7.5 dpc

• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion

decreased embryo size ( J:45074 )

• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos

abnormal visceral endoderm morphology ( J:45074 )

• at 7.5 dpc, the mutant visceral endoderm appears to proliferate relatively longer and forms a thickened columnar layer instead of the unicellular flat squamous layer found in wild-type

growth/size/body

embryonic growth retardation ( J:45074 )

• homozygous null embryos display a developmental delay at 7.5 dpc

• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion

decreased embryo size ( J:45074 )

• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos