Phenotypes Associated with This Genotype

Genotype
MGI:3055025

• Allelic Composition: Mia^tm1Rbu/Mia^tm1Rbu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:74659 )

N • homozygotes show normal mammary gland development and are able to feed and raise their offspring normally relative to wild-type

skeleton

skeleton phenotype ( J:74659 )

N • at E15.5, homozygotes display normal gross morphology of the skeletal system and hyaline joint cartilage

abnormal chondrocyte morphology ( J:74659 )

• at 8 months, articular cartilage obtained from homozygous mutant knee joints exhibits an aberrant fibrillar collagen ultrastructure

• both the pericellular-territorial and interterritorial matrix compartments show significant alterations in collagen fiber density, diameter, and arrangement

• in addition, homozygotes display a significant increase in the number and length of chondrocytic microvilli

integument

integument phenotype ( J:74659 )

N • homozygotes exhibit normal morphology, location, and numbers of melanocytes in the dermis, indicating normal melanoblast migration and differentiation