Phenotypes Associated with This Genotype

Genotype
MGI:3054988

• Allelic Composition: Tg(Ins2-Insl3)4Imad/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

ectopic ovary ( J:74295 )

♀ • the ovaries descend into a low intra-abdominal position over the bladder, the presence of a well developed cranial suspensory ligament prevents further descent of the ovaries

♀ • treatment with dihydrotestosterone from E12.5 to E17.5 results in descent of the ovaries into the groin

reproductive system

ectopic ovary ( J:74295 )

♀ • the ovaries descend into a low intra-abdominal position over the bladder, the presence of a well developed cranial suspensory ligament prevents further descent of the ovaries

♀ • treatment with dihydrotestosterone from E12.5 to E17.5 results in descent of the ovaries into the groin

abnormal gubernaculum morphology ( J:74295 )

• abnormal development of the gubernaculum, with a shorter cord and enlarged bulb, results in descent of the ovaries

reduced female fertility ( J:74295 )

♀ • litter size is significantly smaller in transgenic females compared to wild-type however the percent of transgenic and wild-type pups does not differ from the expected ratio

♀ • litter size is normal at E8.5 but reduced by about half at E10.5, E12.5 and E14

skeleton

abnormal gubernaculum morphology ( J:74295 )

• abnormal development of the gubernaculum, with a shorter cord and enlarged bulb, results in descent of the ovaries