About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3054824
Allelic
Composition
Aipl1tm1Visu/Aipl1tm1Visu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aipl1tm1Visu mutation (0 available); any Aipl1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Progressive degeneration of photoreceptors in Aipl1tm1Visu/Aipl1tm1Visu mice

vision/eye
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions
• at P8, outer segments are shorter than normal, disorganized, and fragmented
• degeneration can be detected at P12 with the thickness of the photorecptor layer reduced by half on P14, only a single layer left on P18, and complete loss by 4 weeks of age
• degeneration proceeds from the center out
• no electroretinographic response is seen at any age

nervous system
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions
• at P8, outer segments are shorter than normal, disorganized, and fragmented

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 4; LCA4 604393 J:92617


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory