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Phenotypes Associated with This Genotype
Genotype
MGI:3054824
Allelic
Composition
Aipl1tm1Visu/Aipl1tm1Visu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Progressive degeneration of photoreceptors in Aipl1tm1Visu/Aipl1tm1Visu mice

vision/eye
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions (J:92617)
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions (J:92617)
• at P8, outer segments are shorter than normal, disorganized, and fragmented (J:92617)
• at P8, outer segments are shorter than normal, disorganized, and fragmented (J:92617)
• degeneration can be detected at P12 with the thickness of the photorecptor layer reduced by half on P14, only a single layer left on P18, and complete loss by 4 weeks of age (J:92617)
• degeneration proceeds from the center out (J:92617)
• degeneration can be detected at P12 with the thickness of the photorecptor layer reduced by half on P14, only a single layer left on P18, and complete loss by 4 weeks of age (J:92617)
• degeneration proceeds from the center out (J:92617)
• no electroretinographic response is seen at any age (J:92617)
• no electroretinographic response is seen at any age (J:92617)

nervous system
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions (J:92617)
• at P8, inner segments are enlarged, disorganized, and contain vacuolar inclusions (J:92617)
• at P8, outer segments are shorter than normal, disorganized, and fragmented (J:92617)
• at P8, outer segments are shorter than normal, disorganized, and fragmented (J:92617)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 4; LCA4 604393 J:92617


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory