Mouse Genome Informatics
hm
    Pdcd1tm1Hon/Pdcd1tm1Hon
BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• start to die around 5 weeks of age, 2/3 are dead by 30 weeks

cardiovascular system
• massively enlarged hearts at death
• both ventricles dilated to about 2X normal diameter
• thin right venricular wall
• sporatic fibrosis and scar formation
• impaired pump function of the heart
• reduced movement of the ventricular walls and interventricular septum

immune system
• higher titers of autoantibodies (IgG1)
• deposition of IgG and C3 complement around cardiomyocytes

liver/biliary system
• varying degrees of hepatomegaly

muscle
• reduced movement of the ventricular walls and interventricular septum

vision/eye
• protrusion of eyeballs occurs a few weeks before death

Mouse Models of Human Disease
OMIM IDRef(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:66979