Mouse Genome Informatics
hm
    Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• proliferative response of B cells to anti-IgM is greatly enhanced
• myeloid lineages in the spleen are also increased
• moderate splenomegaly
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

immune system
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• proliferative response of B cells to anti-IgM is greatly enhanced
• myeloid lineages in the spleen are also increased
• moderate splenomegaly
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

Mouse Models of Human Disease
OMIM IDRef(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:50688