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Phenotypes Associated with This Genotype
Genotype
MGI:3054643
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• moderate splenomegaly
• proliferative response of B cells to anti-IgM is greatly enhanced
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

immune system
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• moderate splenomegaly
• proliferative response of B cells to anti-IgM is greatly enhanced
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:50688


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory