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Phenotypes Associated with This Genotype
Genotype
MGI:3054643
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• proliferative response of B cells to anti-IgM is greatly enhanced
• moderate splenomegaly
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

immune system
• proliferative response of B cells to anti-IgM is greatly enhanced
• moderate splenomegaly
• myeloid lineages in the spleen are also increased
• lymphoid cells in the peritoneal cavity increased about 2 fold
• increased numbers of B cells in the spleen
• B1 cells in the peritoneal cavity are increased
• increased T cell independent antigen responses
• T cell dependent antigen responses were normal
• IgG2b levels were increased
• IgG3 levels were 3X normal

growth/size/body
• moderate splenomegaly

cellular
• proliferative response of B cells to anti-IgM is greatly enhanced


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory