Phenotypes Associated with This Genotype

Genotype
MGI:3054015

• Allelic Composition: Shh^{tm1(EGFP/cre)Cjt}/Shh^{tm1(EGFP/cre)Cjt}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pulmonary artery morphology ( J:204743 )

• pulmonary arteries connect to aorta instead of the ouflow tract

abnormal vasculogenesis ( J:204743 )

• embryos have a disorganized vascular endothelial plexus along anterior foregut which does not connect to heart inflow and outflow tracts

abnormal vascular smooth muscle morphology ( J:204743 )

• reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected

absent pulmonary vein ( J:204743 )

• pulmonary veins from left atrium to lung are absent

abnormal atrium myocardium morphology ( J:204743 )

• mutants show reduced muscular development in dorsal wall of atria

abnormal heart left atrium morphology ( J:204743 )

endocrine/exocrine glands

abnormal cystic duct morphology ( J:241569 )

• shortened cystic duct at E14.5

small gallbladder ( J:241569 )

• shortened gallbladder at E14.5

• however, the gallbladder epithelium is histologically normal

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

muscle

abnormal vascular smooth muscle morphology ( J:204743 )

• reduction in vascular and airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is detected

abnormal atrium myocardium morphology ( J:204743 )

• mutants show reduced muscular development in dorsal wall of atria

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

growth/size/body

acephaly ( J:241569 )

• fetuses are headless

liver/biliary system

abnormal cystic duct morphology ( J:241569 )

• shortened cystic duct at E14.5

small gallbladder ( J:241569 )

• shortened gallbladder at E14.5

• however, the gallbladder epithelium is histologically normal

abnormal gallbladder smooth muscle morphology ( J:241569 )

• formation of smooth muscle layers in gallbladders is delayed and defective

abnormal liver development ( J:241569 )

• fetuses exhibit severe growth retardation in the liver without signs of hepatic inflammation

limbs/digits/tail

abnormal limb bone morphology ( J:92504 )

• a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen

skeleton

abnormal limb bone morphology ( J:92504 )

• a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen

respiratory system

abnormal respiratory conducting tube morphology ( J:204743 )

• airway smooth muscle derived from Isl1- and Gli1-positive cardiopulmonary mesoderm progenitors is significantly reduced; airway smooth muscle development is reduced