Mouse Genome Informatics
hm
    Plscr3tm1Sims/Plscr3tm1Sims
129S5/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• increased size of adipocytes
• aberrant accumulation of abdominal fat by 2 months of age

growth/size/body
• body weight elevated by 2 months
• mild obesity at 19 weeks

homeostasis/metabolism
• elevation in plasma leptin at 19 weeks
• mild hyperglycemia by 2 months of age, persisting to at least 6 months
• glucose intolerance by two months of age
• insulin resistance by two months of age
• adipocytes exhibit defective response to exogenous insulin
• low levels of adiponectin - 50% decrease at 8 and 19 weeks
• dyslipidemia
• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages
• greater than 2 fold increase in cholesterol associated with VLDL and LDL at 19 weeks, smaller increase in HDL
• elevated nonesterified fatty acids by 19 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:92404