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Phenotypes Associated with This Genotype
Genotype
MGI:3053798
Allelic
Composition
Plscr3tm1Sims/Plscr3tm1Sims
Genetic
Background
involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plscr3tm1Sims mutation (0 available); any Plscr3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increased size of adipocytes
• aberrant accumulation of abdominal fat by 2 months of age

growth/size/body
• body weight elevated by 2 months
• mild obesity at 19 weeks

homeostasis/metabolism
• elevation in plasma leptin at 19 weeks
• mild hyperglycemia by 2 months of age, persisting to at least 6 months
• glucose intolerance by two months of age
• insulin resistance by two months of age
• adipocytes exhibit defective response to exogenous insulin
• low levels of adiponectin - 50% decrease at 8 and 19 weeks
• dyslipidemia
• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages
• greater than 2 fold increase in cholesterol associated with VLDL and LDL at 19 weeks, smaller increase in HDL
• elevated nonesterified fatty acids by 19 weeks

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:92404


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory