Mouse Genome Informatics
ht
    Fgfr2tm4Lni/Fgfr2+
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

+/+ wildtype and Fgfr2tm4Lni/+ skull phenotypes and histological sections.

craniofacial
• skull base shortening is mainly in the sphenoid region
• at E14.5 chondrocyte proliferation in the basisphenoid-basioccipital synchondrosis is decreased, however by E16.5 proliferation had returned to normal
• at 4 weeks the maxilla is shorter than normal
• rounding is the result of shortening on the rostrocaudal axis
• a few heterozygotes display a lateral deviation of the nasal area resulting in malocclusion and feeding impairment
• one molar is missing at 4 weeks
• heterozygotes display a shortened face

skeleton
• skull base shortening is mainly in the sphenoid region
• at E14.5 chondrocyte proliferation in the basisphenoid-basioccipital synchondrosis is decreased, however by E16.5 proliferation had returned to normal
• at 4 weeks the maxilla is shorter than normal
• rounding is the result of shortening on the rostrocaudal axis
• a few heterozygotes display a lateral deviation of the nasal area resulting in malocclusion and feeding impairment
• significantly more osteoblasts are seen in the long bones
• at 4 weeks the coronal sutures are fused, the lamboid sutures partially fused, and the saggital sutures only partially separable
• at E16.5 increased overlap of the frontal and parietal bones (coronal suture) is seen
• at E14.5 increased proliferation of osteoprogenitors is seen in the frontal and parietal bone fronts of the coronal suture, however by E16.5 proliferation had returned to normal

vision/eye
• protruding eyes are seen
• widely spaced eyes are seen

growth/size/body
• one molar is missing at 4 weeks
• heterozygotes display a shortened face

Mouse Models of Human Disease
OMIM IDRef(s)
Crouzon Syndrome 123500 J:92433