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Phenotypes Associated with This Genotype
Genotype
MGI:3053437
Allelic
Composition
Ceacam1tm2Bcn/Ceacam1tm2Bcn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ceacam1tm2Bcn mutation (1 available); any Ceacam1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• complete resistance to infection with mouse hepatitis virus (MHV-59)
• mice do not develop liver lesions
• demyelination does not occur in spinal cord

digestive/alimentary system
• exhibit a 30% increase in the number of proliferative cells in the colon
• exhibit decreased apoptosis in the colonic villi

homeostasis/metabolism
• when treated with azoxymethane to induce colonic tumors, homozygotes develop greater number of tumors and tumor size is larger, indicating a more rapid progression in the tumor development; tumors are classified as intramucosal carcinomas
• however, homozygotes do not develop tumors spontaneously

neoplasm
• when treated with azoxymethane to induce colonic tumors, homozygotes develop greater number of tumors and tumor size is larger, indicating a more rapid progression in the tumor development; tumors are classified as intramucosal carcinomas
• however, homozygotes do not develop tumors spontaneously


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory