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Phenotypes Associated with This Genotype
Genotype
MGI:3053128
Allelic
Composition		 Klre1tm1Tgi/Klre1tm1Tgi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klre1tm1Tgi mutation (0 available); any Klre1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:92262 )
• allogeneic but not syngeneic cytotoxicity of lymphokine activated killer cells is impaired
• increased colony formation is seen following bone marrow transplant from BALB/c mice in mutants compared to wild-type mice

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:92262 )
• allogeneic but not syngeneic cytotoxicity of lymphokine activated killer cells is impaired
• increased colony formation is seen following bone marrow transplant from BALB/c mice in mutants compared to wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory