Phenotypes Associated with This Genotype

Genotype
MGI:3052841

• Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods
• Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased leukocyte cell number ( J:43602 )

• 4-5 fold increase in leukocytosis

abnormal spleen morphology ( J:43602 )

enlarged spleen ( J:43602 )

abnormal spleen white pulp morphology ( J:43602 )

• B and T cell areas poorly demarcated and poorly organized

• deficiency of IgM-high IgD-low B cells

decreased immunoglobulin level ( J:43602 )

• deficient in all serum Ig isotypes except IgM

immune system

increased leukocyte cell number ( J:43602 )

• 4-5 fold increase in leukocytosis

abnormal spleen morphology ( J:43602 )

enlarged spleen ( J:43602 )

abnormal spleen white pulp morphology ( J:43602 )

• B and T cell areas poorly demarcated and poorly organized

• deficiency of IgM-high IgD-low B cells

decreased immunoglobulin level ( J:43602 )

• deficient in all serum Ig isotypes except IgM

absent Peyer's patches ( J:43602 )

absent lymph nodes ( J:43602 )

• lacks lymph nodes

growth/size/body

enlarged spleen ( J:43602 )