Phenotypes Associated with This Genotype

Genotype
MGI:3052545

• Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj; Gli3^Xt-J/Gli3^Xt-J
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased motor neuron number ( J:92067 )

• reduced numbers of motor neurons in the thoracic and lumbar cord of embryos

• motor neuron progenitors shifted to more ventral locations and increased 20% in thoracic region while being reduced about 15% in lumbar region

abnormal ventral interneuron morphology ( J:92067 )

• V1, V2a, and V2b interneurons expand down into the ventral midline becoming intermingled with one another and with motor neurons in embryos

abnormal ventral interneuron 0 morphology ( J:92067 )

• V0 interneurons are normal but increased in numbers in embryos

abnormal ventral interneuron 1 morphology ( J:92067 )

• V1 interneurons are also increased in numbers but only in the thoracic region of embryos

abnormal ventral interneuron 2 morphology ( J:92067 )

• V2 interneurons are reduced in number in embryos

abnormal ventral interneuron 3 morphology ( J:92067 )

• V3 interneurons absent in thoracic and lumbar spinal cord of embryos