Phenotypes Associated with This Genotype

Genotype
MGI:3052475

• Allelic Composition: Ods^{Tg(Dct-Tyr)1220Ove}/Ods^{Tg(Dct-Tyr)1220Ove}
• Genetic Background: FVB-Ods^{Tg(Dct-Tyr)1220Ove}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

primary sex reversal ( J:66268 )

• XX mice develop testes with Sertoli cells but no germ cells

• caused by upregulation of SOX9

secondary sex reversal ( J:66268 )

• XX mice develop internal and external male genitalia

vision/eye

cataract ( J:66268 )

abnormal eye development ( J:66268 )

microphthalmia ( J:66268 )

• caused by inappropriate expression of SOX9 in the retinal pigmented epithilium

pigmentation

abnormal coat/hair pigmentation ( J:66268 )

• light coat color and pigmented ears co-segregate with the transgene whcih containes a tyrosinase mingene providing an easliy detectable visual marker

integument

abnormal coat/hair pigmentation ( J:66268 )

• light coat color and pigmented ears co-segregate with the transgene whcih containes a tyrosinase mingene providing an easliy detectable visual marker