Phenotypes Associated with This Genotype

Genotype
MGI:3052421

• Allelic Composition: Hr^tm1Cct/Hr^tm1Cct
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

alopecia ( J:92053 )

• first postnatal hair coat grows normally

• hair loss begins around age 18 and starts at the head, proceeding caudally in a scattered pattern

• hair follicles fail to regenerate

dilated piliary canal ( J:92053 )

• by day 12, pilary canal widens to form a utricle

abnormal skin morphology ( J:92053 )

dermal cyst ( J:92053 )

• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant

wrinkled skin ( J:92053 )

• skin becomes progressively more wrinkled with age

skin hyperplasia ( J:92053 )

• increased cell proliferation in epidermis and utricles

growth/size/body

dermal cyst ( J:92053 )

• small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant