Phenotypes Associated with This Genotype

Genotype
MGI:3052419

• Allelic Composition: Lgr4^{Gt(pGT0TMpfs)1Wcs}/Lgr4^{Gt(pGT0TMpfs)1Wcs}
• Genetic Background: involves: 129P2/Ola * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:92077 )

• fewer than expected homozygotes are found at E19.5 and a further decrease is seen in the first day after birth

• Background Sensitivity: when outcrossed to the CD-1 strain for 6 generations, homozygotes display no intrauterine or perinatal lethality and are obtained at the expected Mendelian ratio at P7

endocrine/exocrine glands

enlarged testis ( J:92077 )

♂ • both males displayed swollen testes

growth/size/body

decreased body weight ( J:92077 )

• a 14% and 20% reduction in body weight is observed on P0 and P1, respectively

• the heart, lung, thymus and spleen show a reduction in absolute weight in proportion with the reduction in body weight

liver/biliary system

decreased liver weight ( J:92077 )

• absolute and relative liver weight are reduced; however, no structural or functional abnormalities are detected

renal/urinary system

abnormal kidney morphology ( J:92077 )

• both mature males displayed swollen kidneys

decreased kidney weight ( J:92077 )

• absolute and relative kidney weight are reduced however no structural or functional abnormalities are detected at birth

reproductive system

enlarged testis ( J:92077 )

♂ • both males displayed swollen testes

enlarged uterus ( J:92077 )

♀ • the one mature female displayed an enlarged uterus

infertility ( J:92077 )

• none of the surviving homozygotes (2 male, 1 female) were fertile