Phenotypes Associated with This Genotype

Genotype
MGI:3052340

• Allelic Composition: Cckar^tm1Kpn/Cckar^tm1Kpn
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased intestinal cholesterol absorption ( J:91998 )

• percent cholesterol absorption values are increased in mutants on a lithogenic diet compared to wild-type mice

abnormal small intestinal transit time ( J:91998 )

• small intestinal transit time is increased in mutants on both normal chow and lithogenic diets

homeostasis/metabolism

increased intestinal cholesterol absorption ( J:91998 )

• percent cholesterol absorption values are increased in mutants on a lithogenic diet compared to wild-type mice

abnormal bile salt homeostasis ( J:91998 )

• the bile salt pool is larger in mutants on a lithogenic diet compared to wild-type mice

abnormal cholesterol homeostasis ( J:91998 )

• increased cholesterol is seen in the gall bladder and hepatic bile in mutants on a lithogenic diet compared to wild-type mice

liver/biliary system

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice

gallstones ( J:91998 )

• on a lithogenic diet significantly more gallstones are found in mutants

abnormal bile composition ( J:91998 )

• the cholesterol content of the bile salts is increased in mutants on a lithogenic diet compared to wild-type mice

endocrine/exocrine glands

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice

growth/size/body

increased gallbladder volume ( J:91998 )

• on a lithogenic diet gall bladder volumes are greater in mutants compared to wild-type mice