Phenotypes Associated with This Genotype

Genotype
MGI:3052339

• Allelic Composition: Cckar^tm1Kpn/Cckar^tm1Kpn
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

abnormal rostral migratory stream morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

abnormal postnatal subventricular zone morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone leading to fewer migrating neuroblasts compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

decreased neuronal precursor cell number ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

liver/biliary system

gallstones ( J:53711 )

• mutants are prone to developing gallstones

behavior/neurological

abnormal food intake ( J:53711 )

• basal food and water intake are normal however treatment with CCK-8 fails to inhibit food intake

• blood glucose levels and pancreatic beta cell morphology are also normal

craniofacial

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

respiratory system

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

growth/size/body

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice