Phenotypes Associated with This Genotype

Genotype
MGI:3052314

• Allelic Composition: Myh10^tm2Rsad/Myh10^tm2Rsad
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The hydrocephalus seen in Myh10^tm2Rsad/Myh10^tm2Rsad mice is rescued by Myh9 expression in Myh10^{tm6(Myh9/GFP)Rsad}/Myh10^{tm6(Myh9/GFP)Rsad} mice

cardiovascular system

cardiovascular system phenotype ( J:248868 )

N • epicardial cells exhibit normal migration in vitro in a scratch wound assay

abnormal heart morphology ( J:248868 )

• authors state that mice exhibit similar heart defects as observed in Myh10^ehc homozygotes

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

abnormal fetal cardiomyocyte morphology ( J:92230 )

• the percentage of binucleated cells is increased to 23% from 1% in wild-type

decreased fetal cardiomyocyte number ( J:92230 )

• at E14.5, the number of cardiac myocytes is reduced by about 70% relative to that in wild-type controls

increased fetal cardiomyocyte size ( J:92230 )

• the size of myocytes is increased at E12.5

absent coronary vessels ( J:248868 )

thin ventricular wall ( J:92230 )

• at E12.5 the number of cell layers in the ventricles is reduced to 2 - 3 compared to 4 - 5 in wild-type hearts

increased fetal cardiomyocyte apoptosis ( J:248868 )

• in the myocardium at E14.5

• however, there is no statistically significant change in apoptosis in the epicardium or in the heart at E9.5

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

cellular

increased fetal cardiomyocyte apoptosis ( J:248868 )

• in the myocardium at E14.5

• however, there is no statistically significant change in apoptosis in the epicardium or in the heart at E9.5

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

muscle

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

increased fetal cardiomyocyte apoptosis ( J:248868 )

• in the myocardium at E14.5

• however, there is no statistically significant change in apoptosis in the epicardium or in the heart at E9.5

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

nervous system

hydrocephaly ( J:124610 )

abnormal spinal cord morphology ( J:124610 )

• the spinal cord is obstructed in mutants