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Phenotypes Associated with This Genotype
Genotype
MGI:3052308
Allelic
Composition
Hrrhsl/Hrrhsl
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrrhsl mutation (0 available); any Hr mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death usually at 6- 10 months of age (J:98859)
• death usually at 6- 10 months of age (J:98859)

behavior/neurological
• females do not nurse their young well (J:98859)
• females do not nurse their young well (J:98859)

immune system
• accelerated atrophy with age (J:98859)
• accelerated atrophy with age (J:98859)

hematopoietic system
• accelerated atrophy with age (J:98859)
• accelerated atrophy with age (J:98859)

integument
• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks (J:98859)
• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks (J:98859)
• extensive hyperkeratosis in hair follicles (J:98859)
• extensive hyperkeratosis in hair follicles (J:98859)
• excessively long and curved, especially the toes of the hind limbs (J:98859)
• excessively long and curved, especially the toes of the hind limbs (J:98859)
• repeatedly shed and regrown becoming more abnormal with age (J:92362)
• repeatedly shed and regrown becoming more abnormal with age (J:92362)
• very extensive hyperkeratosis in hair follicles (J:98859)
• very extensive hyperkeratosis in hair follicles (J:98859)
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis (J:98859)
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis (J:98859)
• extensive development of dermal cysts with advancing age leading to thickening of the skin (J:98859)
• extensive development of dermal cysts with advancing age leading to thickening of the skin (J:98859)
• follicular and epidermal hyperkeratosis (J:98859)
• follicular and epidermal hyperkeratosis (J:98859)
• aging mice have a waxy deposition on the skin that peels off in large flakes (J:98859)
• aging mice have a waxy deposition on the skin that peels off in large flakes (J:98859)
• skin becomes loose, forming rhinoceros-like folds (J:98859)
• skin becomes loose, forming rhinoceros-like folds (J:98859)
• skin becomes thick and wrinkled with age (J:98859)
• skin becomes thick and wrinkled with age (J:98859)

cellular
• very extensive hyperkeratosis in hair follicles (J:98859)
• very extensive hyperkeratosis in hair follicles (J:98859)

endocrine/exocrine glands
• accelerated atrophy with age (J:98859)
• accelerated atrophy with age (J:98859)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory