Mouse Genome Informatics
involves: BALB/c
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• death usually at 6- 10 months of age

• females do not nurse their young well (J:98859)

immune system
• accelerated atrophy with age

hematopoietic system
• accelerated atrophy with age

• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks
• extensive hyperkeratosis in hair follicles
• excessively long and curved, especially the toes of the hind limbs
• repeatedly shed and regrown becoming more abnormal with age
• very extensive hyperkeratosis in hair follicles
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis
• extensive development of dermal cysts with advancing age leading to thickening of the skin
• follicular and epidermal hyperkeratosis
• aging mice have a waxy deposition on the skin that peels off in large flakes
• skin becomes loose, forming rhinoceros-like folds
• skin becomes thick and wrinkled with age

• very extensive hyperkeratosis in hair follicles

endocrine/exocrine glands
• accelerated atrophy with age

Mouse Models of Human Disease
Alopecia Universalis Congenita; ALUNC 203655 J:98859
Atrichia with Papular Lesions; APL 209500 J:98859