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Phenotypes Associated with This Genotype
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrrhsl mutation (0 available); any Hr mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• death usually at 6- 10 months of age

• females do not nurse their young well

immune system
• accelerated atrophy with age

hematopoietic system
• accelerated atrophy with age

• coat is normal up to 12 days when hair loss starts to occur, first around the eyes and progressing in the direction of the tail, with total loss within 2 weeks
• extensive hyperkeratosis in hair follicles
• excessively long and curved, especially the toes of the hind limbs
• repeatedly shed and regrown becoming more abnormal with age
• very extensive hyperkeratosis in hair follicles
• formation of hypertrophic and excessively large utriculi that were filled with masses of cornified material in the dermis
• extensive development of dermal cysts with advancing age leading to thickening of the skin
• follicular and epidermal hyperkeratosis
• aging mice have a waxy deposition on the skin that peels off in large flakes
• skin becomes loose, forming rhinoceros-like folds
• skin becomes thick and wrinkled with age

• very extensive hyperkeratosis in hair follicles

endocrine/exocrine glands
• accelerated atrophy with age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory