Analysis Tools
mortality/aging
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• homozygotes fail to thrive and die before weaning
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digestive/alimentary system
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• villi fuse to form abnormal cauliflower shaped aggregations in which the cells remain stratified rather than becoming to columnar
• abnormal villi can be seen by E15.5
• the morphological complexity of these aggregations increases as mutants age
• microvilli are short, thick, and nonuniform compared to wild-type
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