Phenotypes Associated with This Genotype

Genotype
MGI:3052165

• Allelic Composition: Ntf3^tm1Jae/Ntf3^tm1Jae
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:43444 )

• mutants die soon after birth from cardiac defects

nervous system

absent muscle spindles ( J:43444 )

• no spindle bundles are seen

abnormal dorsal root ganglion morphology ( J:43444 )

• a 63% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice

absent proprioceptive neurons ( J:43444 )

• essentially no proprioceptive neurons are present

muscle

absent muscle spindles ( J:43444 )

• no spindle bundles are seen