Phenotypes Associated with This Genotype

Genotype
MGI:3052162

• Allelic Composition: Ntf3^tm1Jae/Ntf3^tm1Jae; Tg(Myog-Ntf3)5160Wds/0
• Genetic Background: involves: C57BL/6 * CBA * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:43444 )

• mutants die soon after birth presumably from cardiac defects similar to Ntf3^tm1Jae homozygotes

nervous system

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen

abnormal dorsal root ganglion morphology ( J:43444 )

• a 54% decrease compared to wild-type in the overall number of dorsal root ganglia neurons at L4 is seen in newborn mice this represents a partial recovery from the 63% deficiency seen in Ntf3^tm1Jae homozygotes

abnormal proprioceptive neuron morphology ( J:43444 )

• the number of proprioceptive neurons and spindle bundles are decreased in most skeletal muscles however this decrease is not as great as in Ntf3^tm1Jae homozygotes

• this rescue is muscle specific with no recovery in the soleus muscles and almost complete recovery in the medial gastrocnemius

muscle

abnormal muscle spindle morphology ( J:43444 )

• abnormal clusters of spindle bundles are seen