Phenotypes Associated with This Genotype

Genotype
MGI:3052046

• Allelic Composition: Cd4^tm1Mak/Cd4^tm1Mak
• Genetic Background: PL.129S2(B6)-Cd4^tm1Mak/Rdgz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

brain inflammation ( J:92227 )

• severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV

increased susceptibility to Picornaviridae infection ( J:92227 )

• inflammation persists in the susceptible PL/J background, particularly in the cerebellum, brainstem and striatum

nervous system

brain inflammation ( J:92227 )

• severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV

demyelination ( J:92227 )

• demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV