Phenotypes Associated with This Genotype

Genotype
MGI:3052045

• Allelic Composition: Cd4^tm1Mak/Cd4^tm1Mak
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:68957 )

• peripheral CD8+ cell population is expanded

abnormal CD4-positive, alpha-beta T cell physiology ( J:68957 )

• no response to class II alloantigens, but normal class I

immune system

increased CD8-positive, alpha-beta T cell number ( J:68957 )

• peripheral CD8+ cell population is expanded

abnormal CD4-positive, alpha-beta T cell physiology ( J:68957 )

• no response to class II alloantigens, but normal class I

increased susceptibility to Picornaviridae infection ( J:92227 )

• significantly increased inflammation in the first week of TMEV infection which is mostly resolved by 45 days after infection on the resistant C57BL/6 background

• persistent infectious virus at 45 days and increasing clinical symptoms over time

• at 10 months, 93% of mice present clinical symptoms on the resistant C57BL/6 background

nervous system

demyelination ( J:92227 )

• on the resistant C57BL/6 background, demyelination was light at 45 days after TMEV infection, but extensive at 90 days