Phenotypes Associated with This Genotype

Genotype
MGI:3051987

• Allelic Composition: Bdnf^tm3Jae/Bdnf^tm3Jae; Tg(Eno2tTA)5030Nes/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:91563 )

• no response is seen to the antidepressant desipramine in mutants when doxycycline treatment is stopped at 3 months of age

abnormal contextual conditioning behavior ( J:91563 )

• contextual learning is impaired in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline

• contextual learning is virtually absent in mutants when no doxycycline treatment is given throughout development

abnormal cued conditioning behavior ( J:91563 )

• cued learning is normal in mutants when doxycycline treatment is stopped at 3 months of age but impaired when no doxycycline treatment is given throughout development

hyperactivity ( J:91563 )

• mutants bred without doxycycline treatment are hyperactive compared to mutants bred with doxycycline treatment

• hyperactivity is not seen when doxycycline treatment is stopped at 3 months of a

nervous system

reduced long-term potentiation ( J:91563 )

• long term potentiation is impaired requiring a greater amplitude stimulus to evoke any response in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline