Phenotypes Associated with This Genotype

Genotype
MGI:3051904

• Allelic Composition: Socs1^tm1Jni/Socs1⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91651 )

• 50% of homozygotes die within 3 weeks of dimethylnitrosamine (DMN) while 90% of wild-type controls survive

neoplasm

increased hepatoma incidence ( J:91651 )

• increase in liver tumors induced by diethylnitrosamine

• more of an increase in males than in females

• hyperplastic nodules with mild or no dysplasia

immune system

abnormal cytokine level ( J:91651 )

• plasma levels of various cytokines are increased

• IFN gamma levels increased

• increased TGF beta production

abnormal interleukin level ( J:91651 )

• levels are increased

liver/biliary system

abnormal liver morphology ( J:91651 )

• increased succeptibility to liver fibrosis due to diet or dimethylnitrosamine (DMN)

• liver damage is more severe

increased hepatoma incidence ( J:91651 )

• increase in liver tumors induced by diethylnitrosamine

• more of an increase in males than in females

• hyperplastic nodules with mild or no dysplasia

homeostasis/metabolism

abnormal cytokine level ( J:91651 )

• plasma levels of various cytokines are increased

• IFN gamma levels increased

• increased TGF beta production

abnormal interleukin level ( J:91651 )

• levels are increased

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91651 )

• 50% of homozygotes die within 3 weeks of dimethylnitrosamine (DMN) while 90% of wild-type controls survive