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Phenotypes Associated with This Genotype
Genotype
MGI:3051529
Allelic
Composition
Cyb5r4tm1Hfb/Cyb5r4tm1Hfb
Genetic
Background
involves: 129S4/SvJae * BALB/cAnN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyb5r4tm1Hfb mutation (2 available); any Cyb5r4 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Immunohistochemical and ultrastructural assessment of insulin- and glucagon-producing cells in Cyb5r4tm1Hfb/Cyb5r4tm1Hfb mice

homeostasis/metabolism
• early defect in glucose stimulated insulin secretion but not in glucose sensing pathway (J:91486)
• early defect in glucose stimulated insulin secretion but not in glucose sensing pathway (J:91486)
• normal glucose levels at 4 weeks of age in a fed state (J:91486)
• by 7 weeks of age blood glucose is 3X normal in the fed state or after overnight fasting (J:91486)
• normal glucose levels at 4 weeks of age in a fed state (J:91486)
• by 7 weeks of age blood glucose is 3X normal in the fed state or after overnight fasting (J:91486)
• insulin levels 40% of normal at 4 weeks of age (J:91486)
• insulin levels 25% normal at 7 weeks of age and barely detectable after fasting (J:91486)
• insulin levels 40% of normal at 4 weeks of age (J:91486)
• insulin levels 25% normal at 7 weeks of age and barely detectable after fasting (J:91486)
• impaired tolerance for glucose given ip at 4 weeks of age (J:91486)
• impaired tolerance for glucose given ip at 4 weeks of age (J:91486)
• insulin tolerance is normal but with a slight increase in insulin sensitivity (J:91486)
• insulin tolerance is normal but with a slight increase in insulin sensitivity (J:91486)

endocrine/exocrine glands
• decreased cytoplasm to nuclear ratio in islet cells (J:91486)
• no inflammatory cells or necrotic beta cells (J:91486)
• cell distribution pattern normal at 4 weeks of age (J:91486)
• decreased cytoplasm to nuclear ratio in islet cells (J:91486)
• no inflammatory cells or necrotic beta cells (J:91486)
• cell distribution pattern normal at 4 weeks of age (J:91486)
• beta cell numbers decreased at 7 weeks of age (J:91486)
• at 21 weeks a very small number of beta cells are left (J:91486)
• increased size and number of mitochondria (J:91486)
• beta cell numbers decreased at 7 weeks of age (J:91486)
• at 21 weeks a very small number of beta cells are left (J:91486)
• increased size and number of mitochondria (J:91486)
• early defect in glucose stimulated insulin secretion but not in glucose sensing pathway (J:91486)
• early defect in glucose stimulated insulin secretion but not in glucose sensing pathway (J:91486)

adipose tissue
• decreased adipose tissue mass (J:91486)
• decreased adipose tissue mass (J:91486)

behavior/neurological
• increased food intake (J:91486)
• increased food intake (J:91486)

growth/size/body
• decreased adipose tissue mass (J:91486)
• decreased adipose tissue mass (J:91486)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:91486


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory