Phenotypes for Gnas MGI:3051503 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gnas^Oedsml/Gnas^tm1Jop
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas^Oedsml mutation (2 available); any Gnas mutation (66 available)
Gnas^tm1Jop mutation (2 available); any Gnas mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart size ( J:91717 )

• the heart weight to body length ratio is significantly reduced compared to wild-type littermates, however neither heart weight nor body length alone are significantly reduced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:91717 )

N	• unlike Gnas^Oedsml-mat heterozygotes, compound heterozygotes are viable and do not display hypocalcemia, hyperphosphatemia, elevated circulating parathyroid hormone levels, gross edema, or brown fat abnormalities

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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