Phenotypes Associated with This Genotype

Genotype
MGI:3051422

• Allelic Composition: Rr29^Hx/Rr29⁺
• Genetic Background: B10.D2/nSn-Rr29^Hx/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal zone of polarizing activity morphology ( J:27442 )

• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds

polydactyly ( J:27442 , J:87798 )

• a III-II-II-III-IV-V digit pattern (J:27442)

• preaxial polydactyly (J:87798)

• supernumerary metacarpals, metatarsals, and digits (J:87798)

• hindlimbs usually more affected than forelimbs (J:87798)

abnormal tarsal bone morphology ( J:27442 )

• mirror-image duplication of the second and third tarsal bones

abnormal talus morphology ( J:87798 )

• short talus

short radius ( J:87798 )

short tibia ( J:87798 )

hemimelia ( J:87798 )

• hemimelia caused by shortening of the radius, tibia, and talus

skeleton

abnormal tarsal bone morphology ( J:27442 )

• mirror-image duplication of the second and third tarsal bones

abnormal talus morphology ( J:87798 )

• short talus

short radius ( J:87798 )

short tibia ( J:87798 )

homeostasis/metabolism

increased bleeding time ( J:31800 )

• bleeding time is increased 2.6- to 3-fold compared to controls

• platelet numbers and function appear normal

embryo

abnormal zone of polarizing activity morphology ( J:27442 )

• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds