Phenotypes Associated with This Genotype

Genotype
MGI:3051020

• Allelic Composition: Cux1^tm1Mbu/Cux1^tm1Mbu
• Genetic Background: involves: OF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:71407 )

N • the majority of homozygotes survive on the outbred OF1 background

growth/size/body

postnatal growth retardation ( J:71407 )

• homozygotes are severely growth-retarded

• growth retardation is not caused by dysfunction of the thyroid or pituitary glands

reproductive system

reproductive system phenotype ( J:71407 )

N • surprisingly, matings of OF1 mutant males with wild-type females resulted in litters of normal size, indicating normal male fertility

integument

abnormal coat/ hair morphology ( J:71407 )

• the mutant pelage contains twisted, bifurcated, circle, and corkscrew hair as well as hair with nodules or longitudinal grooving

absent auchene hairs ( J:71407 )

absent awl hair ( J:71407 )

sparse hair ( J:71407 )

• rare survivors (1%) have only a sparse pelage of abnormal hair

• at P7, mutants start to lose most of their pelage hair

absent guard hair ( J:71407 )

absent zigzag hairs ( J:71407 )

abnormal hair follicle morphology ( J:71407 )

• morphogenesis of hair follicles is disrupted in 3-wk-old mutants: they appear misoriented, cystic or even sclerotic, and contain more than one degenerated hair shaft

• scales are absent, suggesting aberrant development of the cuticle cell layers in the hair follicle

absent hair follicle inner root sheath ( J:71407 )

• the inner root sheath is reduced in mutant hair follicles

abnormal hair follicle orientation ( J:71407 )

curly vibrissae ( J:71407 )

• pups are born with curly whiskers

short vibrissae ( J:71407 )

• pups are born with only a few stunted whiskers