Phenotypes Associated with This Genotype

Genotype
MGI:3050659

• Allelic Composition: Cd151^tm1Lka/Cd151^tm1Lka
• Genetic Background: C57BL/6-Cd151^tm1Lka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell proliferation ( J:91605 )

• a significant increase in proliferation of activated T cells is seen

abnormal bone marrow cell number ( J:91605 )

• a slight but significant increase in the number of immature myeloid lineage cells and corresponding decrease in lymphocyte numbers is seen

cellular

decreased keratinocyte migration ( J:91605 )

• keratinocyte migration is significantly impaired

abnormal T cell proliferation ( J:91605 )

• a significant increase in proliferation of activated T cells is seen

immune system

abnormal T cell proliferation ( J:91605 )

• a significant increase in proliferation of activated T cells is seen

homeostasis/metabolism

increased bleeding time ( J:91605 )

• a small but significant increase in mean tail bleeding time and a 3 fold increase in the volume of blood lost is seen

renal/urinary system

renal/urinary system phenotype ( J:139653 )

N • Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit histologically normal kidneys with no signs of proteinuria up to 12 months of age, whereas homozygotes on a FVB/N background develop severe glomerular disease

integument

decreased keratinocyte migration ( J:91605 )

• keratinocyte migration is significantly impaired