Phenotypes Associated with This Genotype

Genotype
MGI:3050292

• Allelic Composition: Mus81^tm1Raz/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91570 )

• only 50% of heterozygotes survive to 1 year compared to 95% of wild-type littermates

neoplasm

increased adenoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and adenoma of the prostate, bladder, or colon

increased lymphoma incidence ( J:91570 )

• mutants have a non-Hodgkin's lymphoma incidence of 0.97

• 7 out of 33 lymphomas showed metastatic potential

• heterozygous mutants had either B cell (5/12) or T cell (7/12) derived lymphomas

increased carcinoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and ductal carcinoma

cellular

chromosome breakage ( J:91570 )

• T cell metaphase spreads show increased chromosomal abnormalities including a mild propensity for aneuploidy

• mutants display increased sensitivity to mitomycin c induced sister chromatid exchange