Phenotypes Associated with This Genotype

Genotype
MGI:3050290

• Allelic Composition: Mus81^tm1Raz/Mus81^tm1Raz
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:91570 )

• mutants are slightly more sensitve to 9 Gy gamma irradiation but not to 7 Gy gamma irradiation

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91570 )

• mutants display increased sensitivity to mitomycin c induced lethality

premature death ( J:91570 )

• only 27% of homozygotes survive to 1 year compared to 95% of wild-type littermates

neoplasm

increased lymphoma incidence ( J:91570 )

• mutants have a non-Hodgkin's lymphoma incidence of 1.00

• 2 out of 12 lymphomas showed metastatic potential

increased B cell derived lymphoma incidence ( J:91570 )

• 3 out of 3 lymphomas examined were classified as B cell derived

increased carcinoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and either comedocarcinoma of the neck or ovarian carcinoma

cellular

chromosome breakage ( J:91570 )

• T cell metaphase spreads show increased chromosomal abnormalities

• mutants display increased sensitivity to mitomycin c induced sister chromatid exchange

immune system

immune system phenotype ( J:91570 )

N • mutants display normal lymphocyte development and activation induced proliferation

reproductive system

reproductive system phenotype ( J:91570 )

N • mutants are fertile with no apparent defect in gametogenesis

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:91570 )

• mutants are slightly more sensitve to 9 Gy gamma irradiation but not to 7 Gy gamma irradiation

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91570 )

• mutants display increased sensitivity to mitomycin c induced lethality