Phenotypes Associated with This Genotype

Genotype
MGI:3047709

• Allelic Composition: Pax3^{tm3.1(Pax7)Buck}/Pax3^Sp
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:90568 )

• perinatal lethality probably related to impaired diaphragm development is seen

cellular

decreased cell proliferation ( J:90568 )

• proliferation of the muscle progenitor cells is reduced about 40% compared to wild-type

muscle

abnormal diaphragm development ( J:90568 )

• development of the diaphragm is impaired as a result of impaired progenitor cell migration

abnormal myogenesis ( J:90568 )

• forelimb muscles and hindlimb palm muscles are absent and hindlimb muscles are reduced

nervous system

spina bifida ( J:90568 )

• failure of neural tube closure is seen at about the same rate as in Pax3^Sp heterozygotes

embryo

spina bifida ( J:90568 )

• failure of neural tube closure is seen at about the same rate as in Pax3^Sp heterozygotes

integument

integument phenotype ( J:90568 )

N • no melanocyte abnormalities are seen