Phenotypes Associated with This Genotype

Genotype
MGI:3047704

• Allelic Composition: Pax3^{tm3.1(Pax7)Buck}/Pax3^{tm3.1(Pax7)Buck}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:90568 )

• perinatal lethality probably related to impaired diaphragm development is seen

cellular

abnormal muscle precursor cell migration ( J:90568 )

• muscle progenitors leave the somite in the ventral region but do not migrate further

decreased cell proliferation ( J:90568 )

• proliferation of the muscle progenitor cells is reduced about 40% compared to wild-type

muscle

abnormal muscle precursor cell migration ( J:90568 )

• muscle progenitors leave the somite in the ventral region but do not migrate further

abnormal muscle development ( J:176192 )

• forelimb muscles are reduced

abnormal diaphragm development ( J:90568 )

• development of the diaphragm is impaired as a result of impaired progenitor cell migration

abnormal myogenesis ( J:90568 )

• hindlimb muscles are normal

• at E11.5 distal ventral limb muscles are absent and distal dorsal and proximal limb muscles are reduced and incorrectly patterned compared to wild-type

• this proximal to distal gradation in muscle loss is also seen at E15.5

nervous system

nervous system phenotype ( J:90568 )

N • neural tube closure and neural crest cell migration are normal

integument

integument phenotype ( J:90568 )

N • no melanocyte abnormalities are seen

embryo

embryo phenotype ( J:176192 )

N • dorsal neural tube closure and somite development observed in Pax3 null mice are rescued