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Phenotypes Associated with This Genotype
Genotype
MGI:3047687
Allelic
Composition		 Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3tm3(Pax7)Buck mutation (0 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle development ( J:90568 )
• limb muscles are absent

nervous system
spina bifida ( J:90568 )
• failure of neural tube closure is seen
absent dorsal root ganglion ( J:90568 )
• the dorsal root ganglia are missing

embryo
abnormal neural crest cell migration ( J:90568 )
• deficient neural crest cell migration is seen
spina bifida ( J:90568 )
• failure of neural tube closure is seen

cellular
abnormal neural crest cell migration ( J:90568 )
• deficient neural crest cell migration is seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory