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Phenotypes Associated with This Genotype
Genotype
MGI:3047648
Allelic
Composition		 Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp/Prndtm1Aag mutation (0 available); any Prnp mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:89232 )
N
• mutants do not develop tremor or ataxia unlike Prnptm2.1Cwe homozygotes

cellular
teratozoospermia ( J:89232 )
• sperm malformations similar to those in Prdntm1Aag are seen

immune system
immune system phenotype ( J:89232 )
N
• immune system function and cell populations are normal

reproductive system
teratozoospermia ( J:89232 )
• sperm malformations similar to those in Prdntm1Aag are seen
male infertility ( J:89232 )
• male but not female mutants are infertile

nervous system
nervous system phenotype ( J:89232 )
N
• mutants maintain intact Purkinje cell layers, have normal size cerebella, and do not develop gliosis unlike Prnptm2.1Cwe homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory