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Phenotypes Associated with This Genotype
Genotype
MGI:3047600
Allelic
Composition		 Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation (1 available); any Cd79a mutation (26 available)
Cd79atm4Cgn mutation (0 available); any Cd79a mutation (26 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
decreased IgD level ( J:91091 )
• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
decreased IgM level ( J:91091 )
• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

immune system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
decreased IgD level ( J:91091 )
• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
decreased IgM level ( J:91091 )
• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory