Phenotypes Associated with This Genotype

Genotype
MGI:3047484

• Allelic Composition: Tg(EIF1AX-Il31ra)1Jagr/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

excessive scratching ( J:91124 )

• excessive scratching resulting in abrasions and lesions

abnormal pilomotor reflex ( J:91124 )

• at 4-8 weeks of age piloerection is seen

hearing/vestibular/ear

thick ears ( J:91124 )

• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type

immune system

abnormal leukopoiesis ( J:91124 )

cutaneous mastocytosis ( J:91124 )

• at 6 months of age an increase in mast cell numbers is seen in the skin

increased B cell number ( J:91124 )

• the overall proportion of B cells is increased resulting in an inverse ration of B to T cells compared to wild-type

increased memory T cell number ( J:91124 )

• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type

decreased T cell number ( J:91124 )

• the overall proportion of T cells is decreased resulting in an inverse ratio of B to T cells compared to wild-type

increased activated T cell number ( J:91124 )

• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type

enlarged lymph nodes ( J:91124 )

• the peripheral lymph nodes are enlarged 2 - 5 fold compared to wild-type

abnormal immune system physiology ( J:91124 )

conjunctivitis ( J:91124 )

• 67% of transgenic mice develop conjunctivitis with swelling around the eye

dermatitis ( J:91124 )

• inflammatory cell infiltration and other features of the skin lesions resemble dermatitis

hematopoietic system

abnormal leukopoiesis ( J:91124 )

cutaneous mastocytosis ( J:91124 )

• at 6 months of age an increase in mast cell numbers is seen in the skin

increased B cell number ( J:91124 )

• the overall proportion of B cells is increased resulting in an inverse ration of B to T cells compared to wild-type

increased memory T cell number ( J:91124 )

• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type

decreased T cell number ( J:91124 )

• the overall proportion of T cells is decreased resulting in an inverse ratio of B to T cells compared to wild-type

increased activated T cell number ( J:91124 )

• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type

vision/eye

conjunctivitis ( J:91124 )

• 67% of transgenic mice develop conjunctivitis with swelling around the eye

craniofacial

thick ears ( J:91124 )

• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type

integument

dermatitis ( J:91124 )

• inflammatory cell infiltration and other features of the skin lesions resemble dermatitis

alopecia ( J:91124 )

• at 8 weeks alopecia is seen in greater than 25% of transgenic mice and by 6 months 80-100% had moderate to severe hair loss

hyperkeratosis ( J:91124 )

• hyperkeratosis is seen particularly in lesional skin

acanthosis ( J:91124 )

• at 6 months acanthosis is seen particularly in lesional skin

growth/size/body

thick ears ( J:91124 )

• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type